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The Allograft with Optimal Handling and Potential Osteoinductive Properties

Accell Connexus outpaces other allograft products in three key ways:
• Superior processing
• Validated in vitro assay to confirm the osteoinductivity of each DBM lot
• Sterile - product is e-beam sterilized

The RPM Carrier

Accell Connexus contains a reverse-phase medium that offers exceptional handling. The result is a graft that is contained and resistant to irrigation. Accell Connexus is moldable without becoming hard, packable into virtually any size or shape defect, and easy to combine with other graft materials.

An independent study of the comparative efficacy of two different bone matrix allografts, in which the RPM product had a higher success rate than the product without RPM.1.

RPM is inert, biocompatible, and safe. The majority of the RPM IsoTis uses is metabolized by the kidneys within the first day, presenting a safe means of excretion.2

Osteoinductivity Assay

Each lot of DBM used to create Accell technology passes a validated in vitro assay to ensure osteoinductivity and maximum bone formation potential.3

E-beam Sterilized

Accell Connexus is irradiated with a low-dose electron beam, a process that has been demonstrated to preserve the osteoinductivity.4,5

References
1 Ziran B et al: Comparative efficacy of 2 different demineralized bone matrix allografts in treating long-bone nonunions in heavy tobacco smokers. American Journal of Orthopaedics, July
2005;329-333.
2 Li C, et al: Disposition of poloxamer 407 in rats following a single intraperitoneal injection assessed using a simplified calorimetric assay. J Pharm Biomed Anal 1996;14:659-665.
3 Kay JF: Validated assay for measuring osteoinductivity of human demineralized bone matrix. IsoTis White Paper, 2005.
4 Wientroub S, Reddi AH: Influence of irradiation on the osteoinductive potential of demineralized bone matrix. Calcif Tissue Int 1988;42:255-260.
5 Kay JF: Effects of electron beam irradiation on the osteoinductivity of demineralized bone matrix. IsoTis White Paper, 2005.